Ankylosing spondylitis

Ankylosing spondylitis is an inflammatory disease of the spine which can result in deformity.  It can cause symptoms of pain in the spine and pelvis and deformity.  Curvature of the spine (forwards or to the side) is referred to as kyphosis.

This condition is associated with a blood immune marker called HLA-B27.  It is also associated with inflammatory changes at the base of the spine (the sacro iliac joints).

Medications that are used to treat ankylosing spondylitis vary in effectiveness, cost and safety.  These include NSAIDs such as ibuprofen to prescription drugs such as sulfasalazine, methotrexate, corticosteroids, adulimumab and secukinumab.